{"id":127309,"date":"2022-03-28T18:22:02","date_gmt":"2022-03-28T22:22:02","guid":{"rendered":"https:/news/wp-json/wp/v2/posts/127309///news/wp-json/wp/v2/posts/127309//www.ucf.edu/news/wp-json/wp/v2/posts/127309//news/news/wp-json/wp/v2/posts/127309//?p=127309"},"modified":"2022-03-28T18:22:02","modified_gmt":"2022-03-28T22:22:02","slug":"student-research-week-how-a-special-bacteria-and-vitamin-d-impact-immunity","status":"publish","type":"post","link":"https:/news/wp-json/wp/v2/posts/127309///news/wp-json/wp/v2/posts/127309//www.ucf.edu/news/wp-json/wp/v2/posts/127309//news/news/wp-json/wp/v2/posts/127309//student-research-week-how-a-special-bacteria-and-vitamin-d-impact-immunity/news/wp-json/wp/v2/posts/127309//","title":{"rendered":"Student Research Week: How a Special Bacteria and Vitamin D Impact Immunity"},"content":{"rendered":"<p>While growing up <strong>Joseph Vaccaro /news/wp-json/wp/v2/posts/127309/u201921MS</news/wp-json/wp/v2/posts/127309//strong> was told that the mind is a beautiful thing that should be used to improve the world.</news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<p>It/news/wp-json/wp/v2/posts/127309/u2019s that parental mantra that helped him discover his path from Montrose, Pennsylvania, to College of Medicine Professor Saleh Naser/news/wp-json/wp/v2/posts/127309/u2019s laboratory at UCF. Naser studies the association of <em>Mycobacterium avium subspecies paratuberculosis</news/wp-json/wp/v2/posts/127309//em>(MAP) with Crohn/news/wp-json/wp/v2/posts/127309/u2019s disease and Type I diabetes. Vaccaro is conducting research in his lab as part of his <a href=/news/wp-json/wp/v2/posts/127309/"https:/news/wp-json/wp/v2/posts/127309///news/wp-json/wp/v2/posts/127309//www.ucf.edu/news/wp-json/wp/v2/posts/127309//degree/news/wp-json/wp/v2/posts/127309//biomedical-sciences-phd/news/wp-json/wp/v2/posts/127309///news/wp-json/wp/v2/posts/127309/">doctoral work in biomedical sciences</news/wp-json/wp/v2/posts/127309//a>. He will be presenting part of his investigation during the Student Scholar Symposium this week. The symposium is part of &nbsp;<a href=/news/wp-json/wp/v2/posts/127309/"https:/news/wp-json/wp/v2/posts/127309///news/wp-json/wp/v2/posts/127309//researchweek.ucf.edu/news/wp-json/wp/v2/posts/127309///news/wp-json/wp/v2/posts/127309/">Student Research Week</news/wp-json/wp/v2/posts/127309//a>, which is free, open to the public and ongoing in the Student Union this week.</news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<p>The graduate student/news/wp-json/wp/v2/posts/127309/u2019s ultimate goal is to become a vaccine designer at a biotechnology company or the Centers for Disease Control and Prevention. He wouldn/news/wp-json/wp/v2/posts/127309/u2019t be the first Knight to do it. <a href=/news/wp-json/wp/v2/posts/127309/"https:/news/wp-json/wp/v2/posts/127309///news/wp-json/wp/v2/posts/127309//www.ucf.edu/news/wp-json/wp/v2/posts/127309//pegasus/news/wp-json/wp/v2/posts/127309//covid-19-big-shot/news/wp-json/wp/v2/posts/127309///news/wp-json/wp/v2/posts/127309/"><strong>Darin Edwards &#8217;97 &#8217;10MS &#8217;11PhD</news/wp-json/wp/v2/posts/127309//strong>&nbsp;was part of the team that created Moderna&#8217;s COVID-19 vaccine</news/wp-json/wp/v2/posts/127309//a>. Vaccaro wants to do his part, too.</news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<figure id=/news/wp-json/wp/v2/posts/127309/"attachment_127311/news/wp-json/wp/v2/posts/127309/" style=/news/wp-json/wp/v2/posts/127309/"max-width: 300px;/news/wp-json/wp/v2/posts/127309/" class=/news/wp-json/wp/v2/posts/127309/"figure/news/wp-json/wp/v2/posts/127309/"><noscript><img decoding=/news/wp-json/wp/v2/posts/127309/"async/news/wp-json/wp/v2/posts/127309/" width=/news/wp-json/wp/v2/posts/127309/"300/news/wp-json/wp/v2/posts/127309/" height=/news/wp-json/wp/v2/posts/127309/"200/news/wp-json/wp/v2/posts/127309/" class=/news/wp-json/wp/v2/posts/127309/"figure-img size-medium wp-image-127311 img-fluid/news/wp-json/wp/v2/posts/127309/" 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https:/news/wp-json/wp/v2/posts/127309///news/wp-json/wp/v2/posts/127309//www.ucf.edu/news/wp-json/wp/v2/posts/127309//wp-content/news/wp-json/wp/v2/posts/127309//blogs.dir/news/wp-json/wp/v2/posts/127309//20/news/wp-json/wp/v2/posts/127309//files/news/wp-json/wp/v2/posts/127309//2022/news/wp-json/wp/v2/posts/127309//03/news/wp-json/wp/v2/posts/127309//SecondaryVacarro1Full.jpg 1200w/news/wp-json/wp/v2/posts/127309/" data-src=/news/wp-json/wp/v2/posts/127309/"https:/news/wp-json/wp/v2/posts/127309///news/wp-json/wp/v2/posts/127309//www.ucf.edu/news/wp-json/wp/v2/posts/127309//news/news/wp-json/wp/v2/posts/127309//wp-content/news/wp-json/wp/v2/posts/127309//blogs.dir/news/wp-json/wp/v2/posts/127309//20/news/wp-json/wp/v2/posts/127309//files/news/wp-json/wp/v2/posts/127309//2022/news/wp-json/wp/v2/posts/127309//03/news/wp-json/wp/v2/posts/127309//SecondaryVacarro1Full-300x200.jpg/news/wp-json/wp/v2/posts/127309/"><figcaption class=/news/wp-json/wp/v2/posts/127309/"figure-caption/news/wp-json/wp/v2/posts/127309/">Joseph Vaccaro /news/wp-json/wp/v2/posts/127309/u201921MS</news/wp-json/wp/v2/posts/127309//figcaption></news/wp-json/wp/v2/posts/127309//figure>/news/wp-json/wp/v2/posts/127309/n<p>Vaccaro shares some of his research findings and why it/news/wp-json/wp/v2/posts/127309/u2019s important to conduct studies.</news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<p><strong>Why are you pursuing your major or field of study?</news/wp-json/wp/v2/posts/127309//strong></news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<p>I/news/wp-json/wp/v2/posts/127309/u2019ve always been fascinated by the mechanisms of infection and immunity. UCF has given me the opportunity to take a closer look at the boundary between host and pathogen in this course of study.</news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<p><strong>What does your research examine and how does it impacts the community?</news/wp-json/wp/v2/posts/127309//strong></news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<p>My research looks at the effects of a bacterium called&nbsp;<em>Mycobacterium avium paratuberculosis</news/wp-json/wp/v2/posts/127309//em>, or MAP, on vitamin D signaling in immune cells. This research is important for patients infected with MAP, which includes people with rheumatoid arthritis and Crohn/news/wp-json/wp/v2/posts/127309/u2019s Disease. The results show that vitamin D supplements may be less effective for reducing inflammation in MAP-positive patients. Most people know that vitamin D is important for bone health, but it/news/wp-json/wp/v2/posts/127309/u2019s also a critical signal for parts of the immune system and a lack of active vitamin D in a type of cell called macrophages leads to increased inflammation and a weakened response to bacterial infection. The data shows that MAP can stop macrophages from processing vitamin D/news/wp-json/wp/v2/posts/127309/u2019s signal in the cell, which lets the bacterium survive longer and cause more damaging inflammation. My colleagues and I discovered that a protein called cathelicidin is responsible for translating the signal from vitamin D into reduced inflammation and pathogen destruction, and MAP survives better when cathelicidin is blocked or absent.</news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<p><strong>How did did you develop the idea for your research project?</news/wp-json/wp/v2/posts/127309//strong></news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<p>My project is part of an ongoing effort in Dr. Saleh Naser/news/wp-json/wp/v2/posts/127309/u2019s laboratory to examine how persistent mycobacterial infection affects the immune system, especially in the context of chronic disease. Previous work has identified changes in nicotine signaling in MAP-positive Crohn/news/wp-json/wp/v2/posts/127309/u2019s patients and worsening rheumatoid arthritis symptoms during MAP infection. A fascinating paper in 2019 discovered that&nbsp;M. (mycobacterium) tuberculosis, which is related to MAP, can interfere with vitamin D signaling in macrophages. Dr. (Ahmad) Qasem, our postdoctoral scholar, reasoned that something similar might be happening during MAP infection.</news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<p><strong>What should people know about your research?</news/wp-json/wp/v2/posts/127309//strong></news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<p>This research hinges on the fact that most vitamin D in the human body is inactive and freely circulates in the blood. The kidneys can activate a small amount of inactive vitamin D during conditions of low calcium, but this isn/news/wp-json/wp/v2/posts/127309/u2019t enough to stimulate the immune cells and it can/news/wp-json/wp/v2/posts/127309/u2019t be fixed with normal commercial supplements, which are inactive. However, since MAP is susceptible to certain commercial antibiotic cocktails, the problem of blocked vitamin D signaling may be fixable in MAP-positive patients, which is what we are aiming to help people with.</news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<p><strong>Why does research matter to you?</news/wp-json/wp/v2/posts/127309//strong></news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<p>I was raised to believe that our minds are a gift, and that knowledge is a tool to make the world a better place. Every bit of knowledge we create about human health is one tiny step towards easing suffering and making someone else/news/wp-json/wp/v2/posts/127309/u2019s life safer and better. I will always be proud to be a part of that process.</news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<p><strong>Why did you choose UCF?</news/wp-json/wp/v2/posts/127309//strong></news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<p>I chose UCF because I was impressed with the breadth of programs and variety of innovative research opportunities offered. It seemed like a place where anyone could find their niche. The location of the campus in sunny Orlando certainly didn/news/wp-json/wp/v2/posts/127309/u2019t hurt either.</news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<p><strong>What are some of your other interests?</news/wp-json/wp/v2/posts/127309//strong></news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n<p>I like to read and write short stories, as well as play tabletop games.</news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n","protected":false},"excerpt":{"rendered":"<p>Ph.D. student <strong>Joseph Vaccaro /news/wp-json/wp/v2/posts/127309/u201921MS</news/wp-json/wp/v2/posts/127309//strong> looks at the role of the bacteria connected to Crohn/news/wp-json/wp/v2/posts/127309/u2019s Disease for potential clues about the body/news/wp-json/wp/v2/posts/127309/u2019s immunity system.</news/wp-json/wp/v2/posts/127309//p>/news/wp-json/wp/v2/posts/127309/n","protected":false},"author":16,"featured_media":127310,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[12,23,27],"tags":[653,11,979,14916,7093],"tu_author":[],"class_list":["post-127309","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-research","category-student-life","tag-burnett-school-of-biomedical-sciences","tag-graduate-studies","tag-college-of-medicine","tag-research","tag-student-research-week"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v28.1) - 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